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N-Acetyl-D-Glucosamine (NAG)

N-acetyl-D-Glucosamine (NAG) is necessary for the production of mucin 1. within the intestinal tract. Adequate amounts of mucin are necessary for optimal intestinal permeability, as well as in it protective effect. It will inhibit the growth of certain microbes, including Entamoeba histolitica.3 NAG is thought to counter the production of endotoxins.2 NAG has been shown to enhance the ability of leukocytes to produce inflammatory mediators4, which may play a role in local immunity5 of the intestinal tract.

It has shown promise in the treatment of various inflammatory conditions throughout the body and in the treatment of Chron's Disease, colitis and inflammatory bowel disease.

NAG can be found in the intestinal support formula, Gastriplex.

NAG can also be given by injection, where it can aid in arthritis, osteoarthritis, and other joint diseases. NAG is not effective for joints when given orally. It must be given by injection to aid in relieving joint diseases. NAG seems equally effective when given by injection or by oral dosing for intestinal disorders.

Gastriplex is used for:

  1. acute diarrhea
  2. chronic case of diarrhea (veterinary exam needed in these cases)
    food intolerance
  3. food allergies
  4. soft formed stools
  5. Giardia (see the section covering giardia for complete information on this cause of diarrhea)

Refernences:

1. Burton A, Anderson F. Decreased incorporation of 14-C-glucosamine relative to 3-H-N-Acetylglucosmine in the intestinal mucosa of patients with inflammatory bowel disease. Am J Gastroenterology, 78:19, 1983.
2.Tanamoto K. Predominant role of the substituents on the hydroxyl groups of 3 hydroxy fatty acids of non reducing glucosamine in lipid A for the endotoxic and antagonistic activity. FEBS Lett 12;351(3):325 9, Sept 1994.
3. Coppi A, et al.Regulation of Entamoeba invadens encystation and gene expression with galactose and N acetylglucosamine. Mol Biochem Parasitol.,102(1):67 77, July 30, 1999.
4.Burton A, Anderson F. Decreased incorporation of 14-C-glucosamine relative to 3-H-N-Acetylglucosmine in the intestinal mucosa of patients with inflammatory bowel disease. Am J Gastroenterology, 78:19, 1983.
5. Kuzlan Pawlaczyk M, et al.Effect of N acetylglucosamine on function of peritoneal leukocytes. Perit Dial Int.;19 Suppl 2:S365 9, 1999

 

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