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Diabenil™
Thorne Research
Ingredients:
| Vanadyl Sulfate | 3mg |
| Chromium (Ultracrome®) | 100mcg |
| Gymnema Sylvestre extract (leaf; 25% Gymnemic Acid) | 200mg |
| Bitter Melon Extract (Fruit), (Vaccinium myrtillus; 25% Athocyanosides) | 80mg |
| Alpha-Lipoic Acid | 100mg |
| Bitter Melon Extract, Momordica charantia (Fruit; 0.5 % Charantin) | 80mg |
| Chercetin Chalone | 400mg |
Comments:
This formula is remarkably helpful in regulating diabetics.
Insulin has long been the major therapy in treating diabetes. In our experience, to maintain optimal health, insulin alone is rarely enough to control all the symptoms of diabetes. Diet and the appropriate herbs make all the difference in maintaining the highest quality of health possible.
Chromium picolinate is added to the formula because it increases glucose uptake into cells. For years it has been called the "Glucose Tolerance Factor." Chromium is probably the least important component of this formula, but may work synergistically with the other components to improve glucose utilization by cells.
Vanadium seems to sensitize cells to insulin when the cell is insulin deficient. Vanadium stimulates the insulin-stimulated glucose transporter type 4 (GLUT4) translocation. This would seem to indicate that vanadium will enhance insulin response on GLUT4 translocation, thus increasing glucose cellular uptake.
Gymnema Sylvestre has been used for years in India. It soothes the stomach, is a diuretic, an astringent, and a tonic. Its primary role as an herb, however, is in diabetes, where it appears to enhance endogenous insulin, possibly by regeneration or revitalization of the residual beta cells in insulin-dependent diabetes mellitus. This increases the activity of enzymes responsible for glucose uptake and utilization.
Momordica
charantia has
hypoglycemic actions and is anti-diabetic in its actions. Muscle content
of facilitative glucose transporter isoform 4 (GLUT4) protein is significantly
increased when Bitter Mellon extract is fed orally to mice. This suggests
that the anti-diabetic effect of MC is derived, at least in part, from
a decrease in insulin resistance because of the increase of GLUT4 protein
content in the plasma membrane of the muscle.
Diabenil
is not only helpful with diabetes, but has been proven in our clinical
practice to be highly beneficial for ferrets with insulinomas. For more
information on insulinomas, click here.
Dosage:
Cats:
- 1/2 capsule daily
Dogs:
- 1-25 lbs= 1/2 to 1 capsule daily
- 25-50 lbs= 1 - 2 capsules daily
- 50-100 lbs= 2 - 3 capsules daily
- (may be best if the dose is divided and given twice daily)
Birds:
- Salt lightly on food
- 1/32 capsule for each 500 grams body weight, placed in food
Ferrets:
- 1/4 capsule twice daily, placed in food
References:
1.
Baker, B. Chromium supplements tied to glucose control. Family Practice
News, 15, 5. July, 1996.
2. Wang J, Yuen VG, McNeill JH. Effect of vanadium on insulin and leptin in Zucker diabetic fatty rats. Mol Cell Biochem. 2001 Feb;218(1-2):93-6.
3.
Li SH, McNeill JH. In vivo effects of vanadium on GLUT4 translocation
in cardiac tissue of STZ-diabetic rats. Mol Cell Biochem. 2001 Jan;217(1-2):121-9.
4.
Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram
K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control
of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol.
1990 Oct;30(3):281-94.
5.
Shanmugasundaram KR, Panneerselvam C, Samudram P, ShanmugasundaramER.
Enzyme changes and glucose utilization in diabetic rabbits: the effect
of Gymnema sylvestre, R.Br. J Ethnopharmacol 1983;7:205-234.
6.
Miura T, Itoh C, Iwamoto N, Kato M, Kawai M, Park SR, Suzuki I.
Hypoglycemic activity of the fruit of the Momordica charantia in type
2 diabetic mice. J Nutr Sci Vitaminol (Tokyo). 2001 Oct;47(5):340-4.