S.A.T.® 450 mg

Thorne Research

Price: S.A.T.® 450 mg
Size: 60 capsules
SAT is one of our most effective products for liver support and liver regeneration

Consider SAT for:

    • Animals taking drugs that have potential for producing liver disease
    • Animals with liver disease
    • Animals that have shown elevated "liver enzymes" before outward signs of liver disease develop

SAT stands for Silybum marianum (milk thistle), Artichoke (Cynara scolymus) and Turmeric (Curcuma longa). These three herbs are an excellent combination to Prevent and to Treat Liver disease. The antioxidant capability of milk thistle helps heal liver cell membranes and helps maintain liver antioxidants such as glutathione. Curcuma inhibits liver inflammation (it inhibits lipoxygenase, thus reducing the production of pro-inflammatory leukotrienes). Artichoke supports liver regeneration and is a protectant against a variety of liver toxins.

The combination of these herbs act synergistically on the liver and may help many types of liver disorders. This product may also help prevent liver disorders in animals taking drugs that have the potential to produce liver disease. A good example of this is the use of phenobarbitol to control seizures. Giving SAT while on phenobarbitol may decrease the incidence of liver disease.

    A well-researched, standardized botanical extract, milk thistle contains potent antioxidants that can protect liver cells from free radical damage, strengthen liver cell membranes, and help maintain the liver's built-in antioxidant system glutathione and superoxide dismutase (SOD).

    In numerous studies, its active ingredient, silymarin, has been utilized to prevent liver cell damage by carbon tetrachloride, ethanol, acetaminophen, mushroom toxins, and benzopyrene from automobile exhaust. Silymarin has also been shown to help maintain the body's normal inflammatory response.

    Of the three flavonoids comprising silymarin, silybin predominates and is the most potent. Siliphos provides the benefits of silymarin (flavonoid complex from milk thistle) and phosphatidylcholine in one compound. Siliphos is a phytosome, a water-soluble flavonoid (in this case, silybin) made lipid-friendly by the addition of phosphatidylcholine. This allows for better incorporation of this liver-protective flavonoid into liver cell membranes.

    Studies indicate the silybin-phosphatidylcholine complex in Siliphos provides superior bioavailability compared to conventional milk thistle products.

    Cynara scolymus (artichoke) has a long history of use in hepatic support.

    Turmeric has been used traditionally in both Chinese and Ayurvedic medicine to support liver function.

    The primary efficacious agent is the yellow pigment curcumin. Curcumin's hepatoprotective activity is likely due to its strong antioxidant activity and potential to maintain the body's normal inflammatory response. Binding curcumin to the hepatoprotective phospholipid phosphatidylcholine (as Meriva) not only increases bioavailability but enhances its hepatoprotective effects.

    Liver disease can be life threatening, and a holistic veterinarian should be consulted. More than one therapy/remedy may be needed. SAT is one of several liver support products we recommend.

    Consider SAT for:

    • Hepatitis
    • The use of all NSAID drugs (non-steroidal antiinflammatory drugs), such as Rimadyl, Caprofen and Metacam
    • Liver Cirrhosis
    • Exposure to liver toxins acute or chronic


    • 1-20 lbs=1/4 to 1/2 capsule twice daily
    • 20-50 lbs=1-2 capsules twice daily
    • 50-100+ lbs=3 capsules twice daily


    • 1/4 capsule twice daily, placed into food


    • Small birds (under 100 grams): a "pinch" twice daily
    • Medium sized birds (100 to 250 grams): 1/16 capsule twice daily
    • Large bird (250-600 grams): 1/8 capsule twice daily
    • Very large birds (greater than 600 grams): 1/4 capsule twice daily

    One capsule contains:

    • Silybin Phytosome* (Silybum marianum extract (seed) / Phosphatidylcholine complex), 150 mg
    • Artichoke extract (leaf) (Cynara scolymus), 150 mg
    • Curcumin Phytosome* (Curcuma longa extract (root) / Phosphatidylcholine complex), 150 mg

    Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide.

    *This product uses Indena S.p.A.'s curcumin phytosome (Meriva<>) and silybin phytosome (Siliphos<>). Meriva and Siliphos are registered trademarks of Indena S.p.A.

    Cynara PE 4:1

    Contains ingredients derived from soy (phytosomes).