Thorne Research

Price: Hepagen
Size: 120 capsules

Liver disease is common in dogs and cats. Veterinary medicine seeks to treat liver disease through vaccinations, and to treat liver disorders using diet modification, glucocorticosteroids to reduce inflammation, and antimicrobial drugs to eliminate bacterial hepatitis. This approach has some value, but, unfortunately, there are no pharmaceuticals that actively regenerate liver tissues.

The liver is remarkable in its ability to regenerate itself after injury, and this formula fills the gap in Western medical therapies. It has products that can help the liver regenerate itself.

This formula powerfully regenerates liver tissue while supporting detoxification pathways that are often failing with liver disease.

Silymarin is a nutraceutical extract from the herb Milk Thistle, Silibum marianum. Silymarin appears to have liver protectant and liver restorative properties. Studies have shown that Silymarin will lower liver enzyme values.

The herb Curcuma, also called Turmeric, may have the ability to help hepatocytes regenerate themselves. With liver damage, oxides and free radicals are often produced.

Lipoic acid is gaining increased attention for its role as a biological antioxidant. As lipoamide, it functions as a cofactor in oxidative decarboxylation reactions of pyruvate, alpha-ketoglutarate and branched chain ketoacids. Dimethylglycine is an effective methyl donor and can assist in liver detoxification.

The detoxification pathways of the liver require certain nutrients, including methylcobalamine, methionine, and pyridoxal-5-phosphate. N-Acetyl-L-Cysteine (NAC) is derived from the amino acid, cycteine, and is a stable thiol compound containing a free sulfhydryl group. NAC is a nutritional precursor for the liver's primary antioxidant, glutathione.

    Dimethylglycine (DMG), 50 mg

        DMG will increase energy to the liver cells and promote liver detoxification and protein metabolism by its ability to donate methyl groups.

    Pyridoxal-5-phosphate, 5 mg

        The liver needs to produce new cells to heal itself, and pyridoxine is needed for cell growth. Pyridoxine is often deficient with cases of liver disease. Its inclusion in this formula will benefit all tissues of the body, as well as the liver.

    Methylcobalamine (vitamin B12), 50 mcg

        B12 is an essential vitamin needed for the formation of new red blood cells and for healthy nerves. It may become deficient in chronic liver disease, causing a variety of problems including anemia.

    Methionine, 100 mg

        Methionine helps metabolize fats, preventing their buildup in the liver (it is a lipotropic). It is also a powerful antioxidant, and helps maintain glutathione. Glutathione is perhaps the liver's most important detoxifier

    Choline Citrate, 20 mg

        Choline is important for the processing of fats and regulation of the gallbladder. Adequate levels of choline will keep fat from being deposited in the liver (it is a lipotrophic agent)

    N-Acetyl-L-Cysteine, 100 mg

        N-Acetyl-L-Cysteine is a powerful liver detoxifier. One of its most important functions is in its ability to recycle glutathione to its reduced state. Glutathione is perhaps the liver's most important antioxidant.

    Milk Thistle (Silymarin 80%), 50 mg

        Silymarin comes from the herb Milk Thistle. It has powerful liver protectant and liver restorative properties. Numerous studies have shown that Silymarin will lower liver enzyme values.

    Turmeric extract (Curcuma longa), 50 mg

        Curcuma, also called Turmeric, has well- documented research supporting its use as a hepatocellular regenerator
    • Liver Disease
    • Exposure to liver toxins
    • Liver poisoning
    • Hepatitis
    • Liver Cancer
    • Cirrhosis of liver
    • Birds, with liver disease
    • Birds, to detoxify, use routinely


    • 1-25 lbs=1/2 capsule twice daily
    • 25-50 lbs=1 capsule twice daily
    • 50-100 lbs= 2 capsules twice daily


    • 1/4 capsule twice daily, start slowly with a tiny amount to allow your cat to get used to the taste


    • Small (under 100 grams)= 1/32 capsule daily on food
    • Medium (100 to 250 grams)= 1/16 capsule daily on food
    • Large (250+)= 1/8 capsule daily food
    • For all birds, mix 1 capsule into 1 cup soft foods (veggies, beans, etc). Feed over three days then remix a new batch
    • For hand feeding birds, place 1/32 capsule into formula and give daily. A pinch into each feeding twice daily
    Active Ingredients per Capsule:
    100 mg
    100 mg
    Dimethylglycine (Hydrochloride)
    50 mg
    Milk Thistle extract (seed) (Silybum marianum)
    50 mg
    Turmeric extract (rhizome) (Curcuma longa)
    50 mg
    Pyridoxal 5'-Phosphate (Vitamin B6)
    5 mg
    Methylcobalamin (Vitamin B12)
    50 mcg

    Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Laurate, Silicon Dioxide.

    Recommended for promoting hepatic support.

    Contains ingredient derived from soy.